Table 1.
Logistic regression analysis with sex as a covariate. Genotype and allele frequencies at rs3094228 in the GD UK cohort and healthy Controls (WTCCC2), subdivided into age of disease onset (aged < 30 years / ≥ 30 years)
| rs3094228 | WTCCC Controls (%) | All GD UK Cohort (%) | GD Aged < 30 Years (%) | GD Aged ≥ 30 Years (%) | |
|---|---|---|---|---|---|
| Genotype frequency | CC | 219 (4) | 39 (8) | 16 (13) | 23 (7) |
| CT | 1680 (31) | 225 (48) | 67 (57) | 158 (45) | |
| TT | 3478 (65) | 205 (44) | 35 (30) | 170 (48) | |
| P value | 2.89 × 10 –18 | 1.90 × 10 –13 | 6.97 × 10 –9 | ||
| Allele frequency | C | 2118 (20) | 303 (32) | 99 (42) | 204 (29) |
| T | 8636 (80) | 635 (68) | 137 (58) | 498 (71) | |
| P value (OR [95% CI]) | 5.08 × 10 –9 (OR 1.76 [1.46-2.13]) | 1.70 × 10 -10 (OR 2.73 [2.00-3.71]) | 0.0008 (OR 1.49 [1.18-1.88]) |
Abbreviations: CI, confidence interval; GD, Graves disease; OR, odds ratio; WTCCC, Wellcome Trust case-control consortium.