PGE2
|
COX |
EP1, EP2, EP3, and EP4
|
Vasodilatation, chemotaxis, cell proliferation, and modulation of immune response |
Epidermal keratinocytes and dermal fibroblasts |
PGD2
|
COX |
CRTH2, DP2 or GPR44 |
Immunomodulation (platelet aggregation) |
Epidermal keratinocytes, mast cells, and Langerhans cells |
PGI2
|
COX |
IP |
Vasodilatation and inhibition of platelet aggregation |
Dermal fibroblasts |
TXA2
|
COX |
TP |
Vasoconstriction and platelet aggregation |
Epidermal keratinocytes |
LTB4
|
5-LOX |
BLT1 and BLT2
|
Chemotaxis |
Infiltrating neutrophils and epidermal keratinocytes (lower levels) |
12-HETE |
12-LOX |
12-HETER |
Chemotaxis, leucocyte migration, cell proliferation |
Epidermal keratinocytes and dermal fibroblasts |
15-HETE |
15-LOX |
PPAR-γ |
Counteract 12-HETE and LTB4 effects, reduces polymorphonuclear leukocytes infiltration, and act as biochemical precursor of LXA4
|
Epidermal keratinocytes, and dermal fibroblasts |