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. 2020 Jul 23;9(8):472–490. doi: 10.1089/wound.2019.1105

Table 1.

Summary of the metabolites from essential PUFAs involved in the inflammatory processes in the skin

Metabolite Pathway Receptors Main Biological Effects Cellular Origin in the Skin
PGE2 COX EP1, EP2, EP3, and EP4 Vasodilatation, chemotaxis, cell proliferation, and modulation of immune response Epidermal keratinocytes and dermal fibroblasts
PGD2 COX CRTH2, DP2 or GPR44 Immunomodulation (platelet aggregation) Epidermal keratinocytes, mast cells, and Langerhans cells
PGI2 COX IP Vasodilatation and inhibition of platelet aggregation Dermal fibroblasts
TXA2 COX TP Vasoconstriction and platelet aggregation Epidermal keratinocytes
LTB4 5-LOX BLT1 and BLT2 Chemotaxis Infiltrating neutrophils and epidermal keratinocytes (lower levels)
12-HETE 12-LOX 12-HETER Chemotaxis, leucocyte migration, cell proliferation Epidermal keratinocytes and dermal fibroblasts
15-HETE 15-LOX PPAR-γ Counteract 12-HETE and LTB4 effects, reduces polymorphonuclear leukocytes infiltration, and act as biochemical precursor of LXA4 Epidermal keratinocytes, and dermal fibroblasts