Table 2.
Summary of the cellular mechanisms involving the intracellular signaling activated by fatty acid receptors during skin wound healing
| Title | Author | Year | Agonist | Pathway | Resollution |
|---|---|---|---|---|---|
| New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice | Silva | 2019 | GQ-11 | PPARγ | Accelerates wound closure in diabetic mice by upregulated anti-inflammatory/pro-healing factors Il-10, Arg-1 and Tgf-b Il-10, Vegf, downregulated Il-1b, IL-6 and Tnf-a. |
| Macrophage PPARγ and impaired wound healing in type 2 diabetes. | Mirza | 2015 | Prostaglandin J2 | PPARγ | Improved healing in diabetic mice, decreased expression of IL-1β, TNF-α, IL-6 and increased VEGF, IGF and TGF-β via NF-kβ signaling in wound diabetic mice |
| Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120. | Arantes | 2016 | Docosahezaenoic (DHA) | FFAR4/GPR120 | Wound healing was accelerated, reduction in the expression of interleukin (IL) 1β and an increase in the expression of IL-6, increase in expression of transforming growth factor β (TGF-β) and the keratinocyte marker involucrum |
| 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. | Liu | 2014 | Arachidonic acid | BLT2 | 12-HHT/BLT2 axis promotes wound healing by accelerating keratinocyte migration through NF-kB–Dependent upregulation of TNF and MMP9 |
| Prostaglandin E2 differentially modulates human fetal and adult dermal fibroblast migration and contraction: implication for wound healing. | Sandulache | 2006 | Prostaglandin E2 | EP2/EP4 | Inhibits fetal and adult fibroblast migration |
| Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. | Nelson | 2013 | Prostaglandin E2 | gpr44 | Decreased WIHN |
| Time heals all wounds—but 12-HHT is faster. | Gus-Brautbar | 2014 | 12-hydroxyheptadecatrienoic acid 12-HHT | BLT2 | Synthetic BLT2 agonist accelerated wound closure in a mouse diabetes model |
| Upregulation of prostaglandin EP4 receptor messenger RNA in fetal rabbit skin wound. | Li | 2000 | Prostaglandin EP4 | EP4 | In normal skin, the EP4 receptor messenger RNA levels were higher in adults than in fetuses. Twelve hours after wounding, the EP4 receptor transcript was remarkably induced in fetal skin wounds but repressed in adult skin wounds |
| Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. | Arai | 2007 | Prostaglandin D2 | Prostanoid DP(1) receptor | Suppressive effect on scratching and its effect of accelerating repair of the disrupted cutaneous barrier |