Table 3.

Summary of systematic review

Year	Fatty acids	Start	Outcome	Treatment	Model	Author
2019	16% Linseed oil, 13% evening primrose oil, 16% olive oil	D0	Speed up WH	Topical	Healthy rat	Ishak103
2018	100 ng of RvD1, RvD2, or RvD4	D0	Speed up WH	Topical	Healthy mice	Hellmann120
2018	100 μM palmitoleic acid	D0	Speed up WH	Topical	Healthy rat	Weimann121
2017	50 μM 16,16-dimethyl PG E2	D0	Restored WIHN	injected	Healthy mice	Zhu69
2017	2% jasmonic acid derivative	D0	Speed up WH	Topical	Human suction blister	Henriet130
2017	60–70% linoleic acid from hyperoxygenated fatty acids	D0	Prevented facial PU	Topical	RCT high risk of PU	Otero123
2016	30 μM of Docosahexaenoic Acid	D0	Speed up WH	Topical	Healthy rat	Arantes84
2016	100 μM alprostadil	D0	Speed up WH	Topical	Healthy mice	Naska110
2015	10 μM Arachidonic acid	D0	Speed up WH	Topical	Healthy mice	Oh113
2015	2 mM T26A PG transporter inhibitor	D0	Speed up WH	Topical	non- and Diabetic Rat	Liu117
2015	50 μM PG J2 in F-127 pluronic gel	D0	Speed up WH	Topical	Diabetic mice	Mirza99
2015	Olive oil vs. hyperoxygenated fatty acid	ND	ND preventing PU	Topical	RCT, high risk of PU	Lupianez-Perez126
2014	10 μM Leukotriene B4	ND	Speed up WH	Topical	non- and Diabetic Rat	Liu95
2014	Extra-virgin olive oil vs. hyperoxygenated fatty acids	ND	ND preventing PU	Topical	RCT, risk of PU	Díaz-Valenzuela125
2013	2.5 mg/mL Lipoic Acid–loaded nanocapsules or LA	D0	Speed up WH	Topical	Healthy rat	Külkamp-Guerreiro127
2013	10% oleic-linoleic mixture in collagen-based films	ND	Speed up WH	Topical	Healthy rat	Santos102
2013	10 μg PG D2	D7	Decreased WIHN	Topical	Healthy mice	Nelson90
2013	hyperoxygenated fatty acids vs. triisostearin	ND	Prevented PU	Topical	RCT, high risk of PU	Torra i Bou124
2012	30 mg/g α-lipoic acid	D0	Speed up WH	Topical	Healthy mice	Leu128
2012	0.003% PGE1	D0	Speed up WH	Topical	Rabbit ear	Arai118
2012	100 μg PGE1	D0	Speed up WH	injected	Healthy rat	Takikawa109
2012	2 mM PG transporter inhibitor	D0	Speed up WH	Topical	Diabetic mice	Syeda118
2012	oleic acid based polymeric bandage	D0	Speed up WH	Topical	Healthy rat	Mohanty106
2011	50 ng/wound 14S,21R-dihydroxy-DHA	D2	Speed up WH	Topical	LOX-deficient Mice	Tian115
2011	50 ng/wound 14S,21R-dihydroxy-DHA	ND	Speed up WH	Topical	Diabetic mice	Tian116
2011	30 μM linolenic or 30 μM oleic acids	D0	OA Speed up WH	Topical	Healthy mice	Cardoso104
2010	50 ng 14S,21-diHDHA or 14R,21-diHDHA	D0	Speed up WH	Topical	Healthy mice	Lu114
2010	0.1 g fatty acid extracts of dried Lucilia sericata larvae	D0	Speed up WH	Topical	Healthy rat	Zhang129
2008	99% 300 μL linoleic acid or 99% 300 μL oleic acid	D0	Increased WBC	Topical	Healthy rat	Pereira101
2008	99 mg/g oleic acid or 48 mg/g icosapentaenoic acid	D0	EPA Speed up OA	Topical	Healthy Pig	Shingel107
2008	23% PA and 21% EPA or 19% AA and 16% PA	ND	Speed up WH	Topical	Burned Rat	Badiu122
2004	30 μM linolenic, 30 μM linoleic, or 30 μM oleic acids	D0	OA Speed up LA Speed down WH	Topical	Healthy mice	Cardoso105
2003	8 μg PGE2	D0	Restored WIHN	Topical	COX inhibited Mice	Kämpfer119
2001	10 μg PGE1 in collagen matrix	D0	Speed up WH	Topical	Healthy Rabbits	Ono111
1999	100 μg/g prostacyclin analogue SM-10902	D0	Speed up WH	Topical	Diabetic mice	Yamamoto112

Fatty acids and by-products used in wound healing.

All outcomes p < 0.05.

WH, wound healing; PU, pressure ulcers; LOX, lipoxygenase; WBC, white blood cell; AA, arachidonic acid; PA, palmitic acid; OA, oleic acid; LA, linoleic acid; EPA, eicosapentaenoic acid; WIHN, wound-induced hair neogenesis, start ND, not described; outcome ND, no difference; RCT, randomized controlled trial.