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. 2020 Jul 24;11:3713. doi: 10.1038/s41467-020-17443-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a While unwinding dsDNA, CMG often pauses owing to engagement with the parental duplex at the fork junction. DNA rezipping-induced CMG backtracking can rescue a stalled helicase. Owing to frequent pausing, CMG unwinds duplex DNA very slowly. b Binding of RPA to the lagging-strand template prevents CMG from engaging with duplex DNA at the fork junction. Thus, in the presence of RPA, CMG unwinds dsDNA at rates similar to its ssDNA translocation rate.