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. 2020 Jul 24;10:12429. doi: 10.1038/s41598-020-69301-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic representation of hydrogel preparation and functionalisation. (b) Hydrogels formed by dissolving HSA in DMEM/F12 with additional sodium chloride (top left), DMEM/F12 (top right), PBS (bottom left) and DI (bottom right). Left panel: before plasma treatment, right panel: after plasma treatment. Black dots printed on paper beneath the well-plate to demonstrate hydrogel opacity. Black arrows point at regions where the hydrogels failed after plasma treatment. (c) SEM images of HSA-DMEM/F12 hydrogel surfaces; plasma-treated and non-plasma treated surfaces.