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. 2020 Jul 24;11(7):574. doi: 10.1038/s41419-020-02777-3

Fig. 1. Inhibition of MLK3 improves cardiac function induced by pressure overload.

Fig. 1

a Schematic outline of experiments performed in panels. Mice were in administration of URMC-099 (10 mg/kg, i.p, every 12 h, 7 days before TAC surgery until 56 days after TAC) or isotype. Sham group was injected with isotype control. b Kaplan–Meier survival plots of different groups sham, TAC and TAC + U-099 subjected to TAC at different time points. EF% (c), FS% (d), LVID; d (e), LVID; s (f), LVEDV (g), LVESV (h), and LV mass (i) of TAC, TAC + U-099, or sham mice after 1, 2, 4, and 8 weeks, respectively. Mean ± SEM, n = 5 biologically independent samples, *P < 0.05, **P < 0.01 vs TAC by one-way ANOVA followed by Tukey’s multiple comparisons test. j–l H&E staining (left panel) and Masson’s trichrome staining (right panel) of hearts from TAC, TAC + U-099, or sham mice after 1, 2, 4, and 8 weeks, respectively. Mean ± SEM, n = 3 biologically independent samples, the lower scale bar indicates 1 mm, and the higher scale bar indicates 100 μm, **P < 0.01 vs TAC by one-way ANOVA followed by Tukey’s multiple comparisons test.