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. 2020 Jul 24;10:12409. doi: 10.1038/s41598-020-68488-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with VEGF trap reduces RNFL thickness in glaucomatous patients. (A) Circular peripapillary OCT scan analysis: An abnormal left eye with its corresponding fundus image (upper left). Red lines in the OCT B-Scan (upper right) indicate the inner and outer borders of the RNFL found by the algorithm. RNFL thicknesses (lower right) plotted over the thickness values measured in healthy subjects of the same age. Mean thickness of the RNFL in the six sectors (lower left). This scan shows a significant decrease (red segment) in the inferior temporal quadrant. B-C: IOP levels in eyes injected with VEGF traps (blue curves, n = 10) or non-injected control eyes (red curves, n = 10) from glaucomatous (B) or non-glaucomatous patients (C). D-E: RNFL thickness of eyes injected with VEGF trap (blue curves, n = 10) or non-injected control eyes (red curves, n = 10) from glaucomatous (D) or non-glaucomatous patients (E). **p < 0.01 compared to the baseline value in the treated group (Friedman test followed by a Dunn’s post hoc test).