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. 2020 Jul 24;6(8):e590. doi: 10.1097/TXD.0000000000001038

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Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 2. — Correlation of baboon serum IgM (left) and IgG (right) antibody binding with CDC (at 50% serum concentration) to GTKO (top), GTKO/β4GalNT2KO (middle), and TKO (bottom) pig PBMCs. On the y axis, the dotted line represents the cut-off value (6.4%) below which there is no cytotoxicity. On the x axis, the dotted line represents the cut-off values (IgM 1.2, IgG 1.1) below which there is no binding. (**P < 0.01). Approximately half of the baboons demonstrated low levels of IgM and IgG binding to GTKO/β4GalNT2KO pig PBMCs, and these correlated with a low CDC of these cells. Low levels of antibody binding or CDC were not documented to GTKO or TKO pig PBMCs. Baboons with low serum antibody binding and low CDC to pig PBMCs (Figures 1 and 2) were not necessarily SPF baboons (see Figure 3). CDC, complement-dependent cytotoxicity; GTKO, α1,3-galactosyltransfearse gene-knockout; PBMCs, peripheral blood mononuclear cells; TKO, triple-knockout.