Table 4.

CTM misclassifications

Misclassification category	Misclassifications detail	Number of misclassifications per trial
		1	2	3	4	5	6	7	8	9	10	All
Stage	Failure to detect metastatic disease status for patient with non-metastatic primary staging but metastatic disease at screening	0	3	0	1	1	3	0	1	3	2	14
	Failure to detect disease stage as not advanced/metastatic	0	0	0	2	0	4	3	0	2	6	17
	Failure to detect absence of measurable disease	0	0	0	4	0	0	0	0	0	0	4
	Detection of metastatic disease but failure to recognize as exclusion	0	0	0	0	0	13	0	0	0	0	13
Diagnosis	Failure to recognize mutation status as exclusion criteria	0	3	0	0	0	0	0	0	0	0	3
	Failure to recognize histology as exclusion criteria	0	0	0	0	0	1	0	0	0	0	1
Treatment	Failure to consider prior therapy as part of exclusion criteria	0	0	0	0	0	0	1	2	2	0	5
	Failure to consider timing of prior therapy as part of exclusion criteria	0	1	0	0	0	0	0	0	0	0	1
	Failure to consider location of prior radiotherapy as part of exclusion criteria	0	0	0	0	0	0	18	0	0	0	18
Pathology	Failure to apply correct logic relating to LFT in context of liver metastasis	0	0	0	0	2	0	0	0	0	0	2
Other	Exclusion rules for sub-cohorts applied to overall study	0	0	0	0	0	1	0	0	0	0	1
	Failure to recognize absence of progressive/recurrent disease	0	0	0	0	0	0	0	0	0	3	3

Abbreviations: CTM: clinical trial matching; LFT: liver function tests.