Fig. 1. Repeated forced swims with the same donepezil groups do not show strong antidepressant-like effects.

Shown are the six FSTs from Experiment 1, where a gap of 7 or 14 days was used for shorter versus longer washout periods, respectively, between swims. In this figure and the subsequent ones, statistically significant inverted u (climbing or swimming) or u-shaped (immobility) dose-response curves are depicted, based on their p values from the randomization test. Colored text (C1, C2, C3, and C4) below each bar denotes which cohort of eight mice was given that dose of donepezil for a given FST. Error bars represent mean ± SEM. For bars: *adjusted p < 0.05 versus vehicle, **adjusted p < 0.01 versus vehicle (or adjusted p value is explicitly shown for a statistical trend). *p < 0.05 for inverted u-shape.