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. 2020 Jul 25;10:255. doi: 10.1038/s41398-020-00928-w

Fig. 4. Prior exposure to donepezil is not necessary for its antidepressant-like effects observed in later swims.

Fig. 4

Shown are the results from Experiment 4, consisting of a new cohort of mice that was given vehicle only injections for FST1, followed 7 days later by donepezil treatment (FST2). Immobility shown here was qualitatively u-shaped, and swimming behavior showed antidepressant-like effects in FST2. Error bars represent mean ± SEM. For bars: *adjusted p < 0.05 versus vehicle, **adjusted p < 0.01 versus vehicle.