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. 2020 Jun 26;146(9):2319–2327. doi: 10.1007/s00432-020-03295-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Tumours with LAG3 positive TILs showed a better overall survival. 70.2 months (95% confidence interval (CI) 1.9–138.5 months) in LAG3 positive tumours compared to a median OS of 26.9 months (95%CI 21.9–31.8 months, p = 0.046) for LAG3 negative tumours. b In early invasive tumours, LAG3 dependent survival difference could not be revealed, the survival difference in the entire patients´ cohort is therefore driven by advanced tumour stages (< pT2) (c)