Fig. 1.

EP3 is associated with KEGG signaling pathways of cancer (a), calcium signaling (b), transforming growth factor-β (TGF-β) (c), ECM receptor interaction (d), adheren junction (e) and cell adhesion molecules (CAMs) (f) in carcinogenesis. KEGG pathway gene sets in EP3 high versus low samples were obtained from The Cancer Genome Atlas (TCGA) dataset with the gene set enrichment analysis (GSEA) software (https://www.software.broadinstitute.org/gsea/index.jsp). Normalized enrichment score (NES), nominal P value and false discovery rate (FDR) are shown in each plot. The cut-off criteria for GSEA were nominal P value < 0.05 and false discovery rate (FDR) < 0.25