Table 1.
Univariate and multivariable logistic regression for analyzing the demographic and related clinical characteristics for developing bone metastases in patients diagnosed with initial NPC (diagnosed 2010–2016).
| Subject characteristics | No. of NPC patients | Univariable | Multivariable | |||
|---|---|---|---|---|---|---|
| Without bone met (N, %) | With bone met (N, %) | OR (95% CI) | P | OR (95% CI) | P | |
| Age | ||||||
| 0-24 | 142 (92.8) | 11 (7.2) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| 25-49 | 757 (90.8) | 77 (9.2) | 1.031 (0.535-1.988) | 0.972 | 1.295 (0.528-2.881) | 0.527 |
| 50-74 | 2066 (94.1) | 129 (5.0) | 0.800 (0.423-1.516) | 0.494 | 0.978 (0.447-2.140) | 0.956 |
| 75+ | 372 (95.4) | 18 (4.6) | 0.620 (0.286-1.346) | 0.227 | 0.813 (0.314-2.103) | 0.667 |
| Gender | ||||||
| Female | 1063 (95.9) | 46 (4.1) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Male | 2474 (92.9) | 189 (7.1) | 1.765 (1.269-2.456) | 0.001 | 1.676 (1.134-2.478) | 0.010 |
| Race | ||||||
| White | 1703 (94.7) | 96 (5.3) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Black | 425 (93.0) | 32 (7.0) | 1.336 (0.883-2.021) | 0.171 | 0.893 (0.537-1.483) | 0.662 |
| Others | 1409 (92.9) | 107 (7.1) | 1.347 (1.014-1.790) | 0.040 | 1.003 (0.711-1.415) | 0.985 |
| Marital status | ||||||
| Married | 1996 (94.1) | 125 (5.9) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Single | 1321 (93.2) | 96 (6.8) | 1.160 (0.882-1.528) | 0.298 | 0.946 (0.664-1.348) | 0.759 |
| Unknown | 220 (94.0) | 14 (6.0) | NA | NA | NA | NA |
| Insurance status | ||||||
| Insured | 2249 (94.7) | 125 (5.3) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Uninsured | 1142 (92.4) | 94 (7.6) | 1.481 (1.123-1.953) | 0.005 | 1.256 (0.903-1.746) | 0.176 |
| Unknown | 146 (90.1) | 16 (9.9) | NA | NA | NA | NA |
| T stage | ||||||
| T0 | 19 (86.4) | 3 (13.6) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| T1 | 1001 (96.3) | 38 (3.7) | 0.240 (0.068-0.848) | 0.027 | 0.455 (0.096-2.149) | 0.320 |
| T2 | 525 (96.0) | 22 (4.0) | 0.265 (0.073-0.964) | 0.044 | 0.457 (0.094-2.229) | 0.333 |
| T3 | 594 (94.3) | 36 (5.7) | 0.384 (0.109-1.358) | 0.137 | 0.632 (0.133-3.018) | 0.566 |
| T4 | 715 (91.1) | 70 (8.9) | 0.620 (0.179-2.147) | 0.451 | 0.917 (0.197-4.266) | 0.911 |
| Unknown | 683 (91.2) | 66 (8.8) | NA | NA | NA | NA |
| N stage | ||||||
| N0 | 797 (96.6) | 28 (3.4) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| N1 | 970 (95.1) | 50 (4.9) | 1.467 (0.915-2.352) | 0.111 | 1.086 (0.630-1.873) | 0.767 |
| N2 | 766 (93.1) | 57 (6.9) | 2.118 (1.333-3.366) | 0.001 | 1.844 (1.085-3.136) | 0.024 |
| N3 | 405 (89.0) | 50 (11.0) | 3.514 (2.179-5.667) | <0.05 | 2.052 (1.166-3.611) | 0.013 |
| Unknown | 599 (92.3) | 50 (7.7) | NA | NA | NA | NA |
| Liver Met | ||||||
| None | 3488 (95.8) | 152 (4.2) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Yes | 48 (37.8) | 79 (62.2) | 37.768 (25.457-55.991) | <0.05 | 23.742 (15.261-36.938) | <0.05 |
| Unknown | 1 (20.0) | 4 (80.0) | NA | NA | NA | NA |
| Brain Met | ||||||
| None | 3519 (94.4) | 209 (5.6) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Yes | 18 (47.4) | 20 (52.6) | 18.708 (9.748-35.904) | <0.05 | 10.372 (4.505-23.676) | <0.05 |
| Unknown | 0 (0.0) | 6 (100.0) | NA | NA | NA | NA |
| Lung Met | ||||||
| None | 3431 (95.3) | 171 (4.7) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Yes | 99 (62.3) | 59 (37.3) | 11.958 (8.367-17.089) | <0.05 | 6.027 (3.835-9.473) | <0.05 |
| Unknown | 7 (58.3) | 5 (41.7) | NA | NA | NA | NA |
| Sequence number | ||||||
| One primary only | 2946 (93.3) | 212 (6.7) | 1 (reference) | 1.0 | 1 (reference) | 1.0 |
| Others | 591 (96.3) | 23 (3.7) | 1.849 (1.192-2.869) | 0.006 | 1.298 (0.777-2.167) | 0.319 |
All factors with unknown data were removed from the Cox and Kaplan–Meier model. NPC: nasopharyngeal carcinoma; IQR: interquartile range; Met: metastases; NA: not available.