Figure 4. Functional Relationships by Gene Ontology (GO) Enrichment Analysis of Protein Regulation Networks and Phosphorylation Regulation Networks.
For each kinase and phosphatase, GO categories enriched among their regulated proteins or phosphoproteins were computed.
(A) Part of the enrichment analysis results on protein effectors using the Uniprot biological pathways database (see Table S3 for full results). Cells with black borders indicate kinases and phosphatases for which known pathways were enriched in their protein effectors.
(B) Part of the enrichment analysis results on phosphoprotein effectors using the Uniprot biological pathways database (see Table S4 for full results). Cells with black borders are the same as in (A).
(C) Examples showed functionally related kinases and phosphatases in regulating proteins involved in glucose import, ergosterol biosynthesis, and proteasome.
(D) Examples of subnetworks of kinases and phosphatases coordinately modulating the TOR signaling pathway and glycolysis.