KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Experimental models: organisms/strains
Saccharomyces cerevisiae kinase/phosphatase deletion strains	Giaever et al., 2002	http://www-sequence.stanford.edu/group/yeast_deletion_project/deletions3.html
Chemicals, Peptides, and Recombinant Proteins
YPD medium	Research Product International	Cat. # Y20090-5000.0
Protease inhibitors	Roche	Cat. # 11836170001
Phosphatase inhibitors	Roche	Cat. # 04906837001
Pierce BCA Protein Assay Kit	ThermoFisher	Cat. # 23225
TMT 11-plex reagents	ThermoFisher	Cat. # 90406, Cat. # A34807
Sep-Pak solid-phase extraction column	Waters	Cat. # WAT036820
High-Select Fe-NTA phosphopeptide enrichment kit	ThermoFisher	Cat. # A32992
Deposited Data
Mass spectrometry data	This paper	ProteomeXchange (PXD015575)
Software and Algorithms
In-house mass spectrometry data analysis software	Huttlin et al., 2010	N/A
Cytoscape 3.6.0	Shannon et al., 2003	https://cytoscape.org/
R 3.4.2	N/A	https://www.r-project.org/
R package “dplyr” 0.7.4	N/A	https://cran.r-project.org/web/packages/dplyr/index.html
R package “pheatmap” 1.0.8	N/A	https://cran.r-project.org/web/packages/pheatmap/index.html
R package “tidyr” 0.8.0	N/A	https://cran.r-project.org/web/packages/tidyr/index.html
R package “tibble” 1.4.2	N/A	https://cran.r-project.org/web/packages/tibble/index.html
Other
Uniprot biological pathway database	UniProt Consortium, 2019	https://www.uniprot.org/
KEGG pathway database	Kanehisa and Goto, 2000	https://www.genome.jp/kegg/
BioGRID protein-protein interaction database	Stark et al., 2006	https://thebiogrid.org/
SGD GO database and protein complex database	Cherry et al., 2012	https://www.yeastgenome.org/