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. 2020 Jul 25;8:112. doi: 10.1186/s40168-020-00886-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Small intestinal microbiota changes and correlation of changed intestinal microbiota after a 2-week AOS dosing. a The PLS-DA of the microflora in different treatments. b Differences of bacterial abundance at the phylum level. c Cladogram. d LDA distribution. Linear discriminate analysis effect size (LEfSe) was performed to determine the difference in abundance; the threshold of LDA score was 4.0 (n = 15 samples/group). e Correlation of intestinal microbiota and blood metabolites. (n = 10 samples/group)