Table 1.
Distribution of stop-gain variation in VPCI591
| Genomic Position | Gene Id | Gene Name | Nucleotide Change | Amino acid changing to stop codon | No. AA lost | Function | Domains lost |
|---|---|---|---|---|---|---|---|
| 162,226 | Rv0134 | ephF | G456A | W152X | 148 | Possible epoxide hydrolase EphF | Hydrolase domain |
| 234,477 | Rv0197 | Rv0197 | T2247G | Y749X | 14 | Possible oxidoreductase | |
| 309,765 | Rv0257 | Rv0257 | C67T | R23X | 102 | Hypothetical protein | |
| 549,251 | Rv0457c | Rv0457c | G357A | W119X | 555 | Probable peptidase | Oligopeptidase domain |
| 704,997 | Rv0610c | Rv0610c | C913T | Q305X | 81 | Hypothetical protein | |
| 1,009,490 | Rv0906 | Rv0906 | C547T | Q183X | 190 | Hypothetical protein | |
| 1,037,911 | Rv0930 | pstA1 | C913T | R305X | 3 | Probable phosphate-transport integral membrane ABC transporter PstA1 | |
| 2,399,782 | Rv2139 | pyrD | C1063T | Q355X | 2 | Probable dihydroorotate dehydrogenase | |
| 2,448,288 | Rv2187 | fadD15 | G129A | W43X | 558 | Actelyco asynthetase like | AMP synthetase ligase |
| 2,882,317 | Rv2563 | Rv2563 | C28T | Q10X | 340 | Probable glutamine-transport transmembrane ABC transporter | Cytoplasmic domain |
| 2,929,354 | Rv2601 | speE | C967T | Q323X | 202 | Spermidine synthatase | |
| 2,936,497 | Rv2608 | PPE42 | C1452A | Y484X | 97 | PPE family protein PPE42 | PPE C-terminal domain |
| 3,097,349 | Rv2788 | sirR | C391T | Q131X | 130 | Probable transcriptional repressor SirR | |
| 3,351,472 | Rv2994 | Rv2994 | G204A | W68X | 377 | Probable integral membrane protein | |
| 3,378,720 | Rv3019c | esxR | G282A | W94X | 3 | Secreted ESAT-6 like protein EsxR | |
| 3,442,240 | Rv3079c | Rv3079c | G358T | E120X | 156 | Hypothetical protein | Luciferase like domain |
| 3,689,523 | Rv3303c | lpdA | C1416A | C472X | 22 | NAD(P) H quinone reductase LpdA | |
| 4,351,039 | Rv3872 | PE35 | G295T | E99X | 1 | PE family-related protein PE35 |