Table 2.

Distribution of stop-loss variation in VPCI591

Genomic Position	Gene Id	Gene Name	Nucleotide Change	Stop codon changing to Amino Acid	Function	AA added	Predicted functiona
392,261	Rv0325	none	T223C	X75Q	Hypothetical protein	155	Class I SAM-dependent methyltransferase
715,266	Rv0621	none	A1065G	X355W	Possible membrane protein	31
932,280	Rv0836c	none	A653G	X218W	Hypothetical protein	23
1,315,191	Rv1180	pks3	A1467C	X489Y	Probable polyketide beta-ketoacyl synthase Pks3	1597	Msl3 (mass like protein3)
1,694,547	Rv1504c	none	T598G	X200E	Hypothetical protein	182
2,020,563	Rv1783	none	A1307T	X436L	ESX-5 type VII secretion system protein	15
2,052,687	Rv1809	PPE33	G1406C	X469S	PPE protein	1
2,120,796	Rv1870c	none	A635T	X212L	Hypothetical protein	11	Endonuclease
3,007,238	Rv2690c	none	T1972C	X658R	Integral membrane alanine and valine and leucine rich protein	6
3,788,365	Rv3373	echA18	T640G	X214G	Probable enoyl-CoA hydratase EchA18	83
4,190,285	Rv3739c	PPE67	A233G	X78W	PPE67	18
4,383,655	Rv3898c	none	T331C	X111Q	Hypothetical protein	215

^aPredicted function of the longer protein resulting from loss of stop codon due to SNV