Table 3.
Risk factors for RFS in CC patients with stage IB-IIA by univariate and multiple Cox regression analysis
| Variables | Univariate Multivariate | |||
|---|---|---|---|---|
| HR(95% CI) | p value | HR(95% CI) | p value | |
| Age (high vs low) | 1.47 (0.97–2.21) | 0.076 | ||
| BMI (high vs low) | 0.99 (0.67–1.48) | 0.923 | ||
| Diabetes (yes vs no) | 1.21 (0.82–1.77) | 0.358 | ||
| Hypertension (yes vs no) | 1.03 (0.63–1.65) | 0.892 | ||
| Hyperlipemia (yes vs no) | 1.11 (0.72–1.61) | 0.628 | ||
| Pathological type (SCC vs non-SCC) | 1.21 (0.30–4.93) | 0.783 | ||
| FIGO stage (IIA vs IB) | 2.33 (1.29–4.24) | 0.009* | 2.11 (1.14–3.79) | 0.017* |
| Tumor grade (G2/3 vs G1) | 1.16 (0.68–2.06) | 0.553 | ||
| Tumor size (≥4 cm vs < 4 cm) | 1.83 (1.26–4.27) | 0.026* | 1.57 (0.88–2.81) | 0.136 |
| Adjuvant therapy (yes vs no) | 1.61 (0.47–5.11) | 0.413 | ||
| LVSI (yes vs no) | 1.09 (0.69–1.69) | 0.676 | ||
| LNM (yes vs no) | 1.59 (1.04–2.49) | 0.029* | 1.84 (1.12–2.88) | 0.032* |
| Depth of invasion(≥2/3 vs < 2/3) | 1.16 (0.46–2.92) | 0.718 | ||
| Vaginal invasion (yes vs no) | 1.24 (0.70–2.21) | 0.411 | ||
| Hemoglobin (high vs low) | 0.74 (0.31–1.79) | 0.521 | ||
| Platelet (high vs low) | 1.11 (0.60–2.04) | 0.712 | ||
| WBC (high vs low) | 1.66 (0.52–5.22) | 0.388 | ||
| Total cholesterol (high vs low) | 1.14 (0.73–1.82) | 0.554 | ||
| CRP (high vs low) | 1.32 (0.49–3.14) | 0.533 | ||
| FAR (> 7.75 vs ≤7.75) | 2.53 (1.24–5.18) | 0.009* | 2.41 (1.36–4.11) | 0.011* |
Abbreviations: CC cervical cancer, BMI body mass index, SCC squamous cell carcinoma, FIGO International Federation of Gynecology and Obstetrics, FAR fibrinogen-to-albumin ratio, LVSI lympho-vascular space invasion, LNM lymphatic node metastasis, WBC white blood cell, CRP C-reactive protein, HR hazard ratio, CI confidence interval
* P < 0.05