Table 4.
Risk factors for OS in CC patients with stage IB-IIA by univariate and multiple Cox regression analysis
| Variables | Univariate Multivariate | |||
|---|---|---|---|---|
| HR(95% CI) | p value | HR(95% CI) | p value | |
| Age (high vs low) | 1.74 (0.88–3.51) | 0.113 | ||
| BMI (high vs low) | 1.11 (0.56–2.14) | 0.751 | ||
| Diabetes (yes vs no) | 1.08 (0.58–2.02) | 0.765 | ||
| Hypertension (yes vs no) | 1.15 (0.61–2.11) | 0.651 | ||
| Hyperlipemia (yes vs no) | 1.43 (0.62–3.22) | 0.357 | ||
| Pathological type (SCC vs non-SCC) | 1.89 (0.92–4.11) | 0.079 | ||
| FIGO stage (IIA vs IB) | 2.91 (1.32–6.14) | 0.008* | 2.72 (1.18–5.01) | 0.022* |
| Tumor grade (G2/3 vs G1) | 0.98 (0.50–1.87) | 0.914 | ||
| Tumor size (≥4 cm vs < 4 cm) | 1.41 (0.56–3.31) | 0.431 | ||
| Adjuvant therapy (yes vs no) | 1.59 (0.93–2.68) | 0.087 | ||
| LVSI (yes vs no) | 2.53 (1.20–5.61) | 0.016* | 1.48 (0.81–2.69) | 0.211 |
| LNM (yes vs no) | 1.84 (0.67–4.79) | 0.211 | ||
| Depth of invasion(≥2/3 vs < 2/3) | 1.41 (1.07–1.87) | 0.018* | 1.22 (0.83–1.77) | 0.281 |
| Vaginal invasion (yes vs no) | 1.33 (0.96–1.78) | 0.081 | ||
| Hemoglobin (high vs low) | 0.70 (0.40–1.24) | 0.265 | ||
| Platelet (high vs low) | 1.55 (0.97–2.47) | 0.061 | ||
| WBC (high vs low) | 1.44 (0.95–2.11) | 0.068 | ||
| Total cholesterol (high vs low) | 1.26 (0.65–2.33) | 0.443 | ||
| CRP (high vs low) | 1.25 (0.84–1.81) | 0.194 | ||
| FAR (> 7.75 vs ≤7.75) | 2.78 (1.56–5.06) | 0.003* | 2.83 (1.41–5.35) | 0.008* |
Abbreviations: CC cervical cancer, BMI body mass index, SCC squamous cell carcinoma, FIGO International Federation of Gynecology and Obstetrics, FAR fibrinogen-to-albumin ratio, LVSI lympho-vascular space invasion, LNM lymphatic node metastasis, WBC white blood cell, CRP C-reactive protein, HR hazard ratio, CI confidence interval
* P < 0.05