Fig. 5.

The convergence of mutated features and their associations for an L-serine tolerization ALE. a The convergence of mutated features from the Mundhada et al. 2017 ALE experiment onto regulons. b A heatmap of the odds ratios for significantly mutated features from the Mundhada et al. 2017 ALE experiment and their significantly associated conditions. Significantly mutated regulon and operons (P < 0.05, permutation test, mutations to feature > 1) were found to be significantly associated (P < 0.01, Fisher’s exact test) with the conditions of L-serine tolerance and the specific E. coli K-12 MG1655 starting strain. These features were associated with both conditions in equal magnitude and significance