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. 2020 Jul 25;13:105. doi: 10.1186/s13041-020-00644-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — HDAC6 and SIRT2 regulate neuronal migration through cortactin deacetylation in vivo. HDAC6 or SIRT2 single knockdown neurons properly migrated into pial surface. However, HDAC6 and SIRT2 double KD neurons and cortactin acetylation mimetic form expressing neurons did not migrate to the pial surface. a HDAC6 and SIRT2 double knockdown neurons did not migrate into cortical plate properly. Neurons overexpressing acetylation mimetic form of cortactin had a defect in radial migration. Scale bar, 50 μm (b) Graphs represent the percentage of transfected cells in the cortical layer. *p < 0.05, **p < 0.01, ***p < 0.001 by two-tailed Student’s t-test. Error bar means ± S.D. in all graphs