Table 1.
Studied morphea therapies*
| Treatment | Effective or Ineffective | Level of Evidence |
|---|---|---|
|
| ||
| Subcutaneous interferon gamma | Ineffective | 1B |
|
| ||
| Oral calcitriol | Ineffective | 1B |
|
| ||
| Topical tacrolimus | Effective | 1B |
|
| ||
| Photodynamic therapy | Ineffective | 2A |
|
| ||
| NB UBV | Effective | 2B |
|
| ||
| UVA1 | ||
| Low dose | Effective | 2B |
| Medium dose | ||
| High dose | ||
|
| ||
| Broadband UVA | Effective | 2B |
|
| ||
| Imiquimod | Effective | 2B |
|
| ||
| PUVA | Effective | 2B |
|
| ||
| Calcipotriol in combination with betamethasone dipropionate | Effective | 2B |
|
| ||
| Methotrexate in combination with systemic steroids | Effective | 2B |
|
| ||
| D-penicillamine | Effective | 3 |
|
| ||
| Cyclosporine | Effective | 3 |
|
| ||
| Mycophenolate mofetil | Effective | 3 |
|
| ||
| Photophoresis | Effective | 3 |
NBUVB, Narrowband ultraviolet B light phototherapy; PUVA, psoralen plus ultraviolet A light phototherapy; UVA1, ultraviolet A light phototherapy.
*
Level of evidence rating scheme from Shekelle et al.66