Table 2.

Amino acid mutations in neutralizing epitopes of the putative S protein of 32 PEDV strains from this study compared with CV777

Strain	Position of amino acid point mutation (position in alignment)
	522	526	528	532	554	599	610	617	640	771
CV777	A	L	S	V	T	G	A	L	I	Y
CH/HJ/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/HY/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/JY/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/KF/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/LY/2015	A→F	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/NH/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/PDS/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/SS/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/XX/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/YY/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→D	L→F	I→V	Y→S
CH/YZ1/2015	A→S	L→Y	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
CH/YZ2/2015	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/XX1/2016	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→Y	I→V	Y→S
HN/XX2/2016	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/XX3/2016	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→Y	I→V	Y→S
HN/XX/2016	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→Y	I→V	Y→S
HN/PY/2016	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
SX/TY1/2017	A	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
SX/TY2/2017	A	L→H	S→G	V→I	T→S	G→S	A→E	L	I→V	Y→S
HN/KF/2017	A	L→R	S→G	V→I	T	G→S	A→E	L→F	I→V	Y→S
HN/XZ/2017	A	L→R	S→G	V→I	T	G→S	A→E	L→F	I→V	Y→S
SX/WS1/2018	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/YY1/2018	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/XC1/2018	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/XC2/2018	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/HB1/2018	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/HB2/2018	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/JY/2018	A	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/HX/2019	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/KF/2019	A→S	L→H	S→G	V→I	T→S	G→S	A→E	L→F	I→V	Y→S
HN/XC/2019	A→S	L→H	S→G	V→I	T→S	G→S	A→D	L→F	I→V	Y→S
SX/YC/2019	A→S	L→R	S→G	V→I	T→S	G→S	A→D	L→F	I→V	Y→S