Fig. 5.

Chaetocin, gemcitabine and lestaurtinib reduce virus yield from infected cells. A549 cells were infected at an MOI of 10 of HAdV for 1 h, and washed with PBS to remove unbound virus before adding medium containing vehicle or compound (chaetocin at 1 μM, gemcitabine at 0.5 μM and lestaurtinib at 5 μM). At 24 hpi, the infected cells were collected into the medium and the titer of virus in the cell lysates were determined by plaque assay. Error bars represent SD of experimental replicates (n = 2).