Table I.

Static and Dynamic Histomorphometry in the Distal Femur

Bone parameter‡	Control (n = 10)	ΔFzd4 (n = 11)
Bone Structure
Bone volume/tissue volume (BV/TV; %)	13.17 ± 0.82	10.74 ± 0.68*
Trabecular Thickness (μm)	32.76 ± 1.81	29.35 ± 1.68
Trabecular Spacing (μm)	212.24 ± 11.47	247.73 ± 11.47*
Bone Formation
Osteoid surface/bone surface (OS/BS; %)	2.29 ± 0.85	2.17 ± 0.39
Osteoid thickness (O.Th; μm)	2.87 ± 0.36	1.73 ± 0.19*
Osteoblast surface/bone surface (Ob.S/BS; %)	0.82 ± 0.30	1.89 ± 0.57
Osteoblast number/bone perimeter (NOb/BPm; no./mm)	48.80 ± 14.18	130.72 ± 32.51*
Bone Erosion
Erosion surface/bone surface (ES/BS; %)	2.40 ± 0.48	2.16 ± 0.42
Osteoclast surface (Oc.S/BS; %)	2.17 ± 0.46	1.90 ± 0.37
Osteoclast number/bone perimeter (NOc/BPm; no./mm)	80.10 ± 16.00	75.45 ± 14.29
Bone Dynamics
Mineral apposition rate (MAR; μm/day)	1.48 ± 0.07	1.07 ± 0.12*
Mineralizing surface/bone surface (MS/BS; %)	9.25 ± 0.86	8.44 ± 1.07
Bone formation rate/bone surface (BFR/BS; mm3/cm2/yr)	51.36 ± 6.32	29.76 ± 3.23*

^‡Values are shown as mean ± SEM

^*p < 0.05