Table 1.
Data and Sources: Depression
| Parameter | Value | Range | Type
of Probability Distribution Used in PSA |
Sources |
|---|---|---|---|---|
| Depression prevalence (%) | ||||
| HIV negative | 17.0 | (12.0, 23.0) | Beta | (Ovuga, Boardman, & Wasserman, 2005) |
| HIV positive | 28.0 | (23.0, 33.0) | Beta | (Breuer, Myer, Struthers, & Joska, 2011) |
| Odds ratios for depression | ||||
| HIV positive, status known | 1.99 | (1.32, 3.00) | Lognormal | (Dickens Akena, Musisi, Joska, & Stein, 2012; Ciesla & Roberts, 2001) |
| CD4 <50 | 2.34 | (1.39, 3.93) | Lognormal | (Kaharuza et al., 2006) |
| Female | 1.85 | (1.24, 2.44) | Lognormal | (Kaharuza et al., 2006; Kinyanda, Hoskins, Nakku, Nawaz, & Patel, 2011) |
| Adherence prevalence (%) | 80.0 | (72.0, 88.0) | Beta | (Mills et al., 2006) |
| Odds ratios for HIV-infected individuals with depression | ||||
| Adherence | 0.32 | (0.11, 0.93) | Lognormal | (Byakika-Tusiime et al., 2009) |
| No leakage | 0.32 | (0.11, 0.93) | Lognormal | Assumed |
| No LTFU | 0.32 | (0.11, 0.93) | Lognormal | Assumed |
| Odds ratio for viral failure due to non-adherence | 9.90 | (3.20, 45.10) | Lognormal | (Obirikorang, Selleh, Abledu, & Fofie, 2013; Weidle et al., 2006) |
| PHQ-9 diagnostic test | ||||
| Sensitivity | 0.92 | (0.83, 1.00) | Beta | (D. Akena et al., 2013) |
| Specificity | 0.81 | (0.73, 0.89) | Beta | (D. Akena et al., 2013) |
| Treatment effects | ||||
| Probability of remission at month 6 of initial therapy | 0.70 | (0.32, 0.79) | Beta | (Ngo et al., 2014; Patel et al., 2003) |
| Probability of remission at month 12 of continuation therapy | 0.40 | (0.36, 0.50) | Beta | (Hollon, Stewart, & Strunk, 2006) |
ART: antiretroviral therapy; LTFU: loss to followup; PHQ-9: Patient Health Questionnaire-9; PSA: probabilistic sensitivity analysis.