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. Author manuscript; available in PMC: 2020 Aug 22.
Published in final edited form as: Mucosal Immunol. 2020 Jan 27;13(5):788–798. doi: 10.1038/s41385-020-0258-x

Figure 1. CK2α Expression in CD4+ T-cells is Required for Colitis.

Figure 1.

C57BL/6 Rag1−/− mice (male or female) were injected i.v. with 1 x 106 naïve CD4+ T-cells from sex and age-matched CK2αfl/fl, dLck-Cre or CK2αfl/fldLck-Cre mice at the age of 8-10 weeks. Body weight of recipients was monitored weekly. Seven weeks after transfer, mice were sacrificed and assessed for intestinal inflammation. (A) Weight change of recipient mice. CK2αfl/fl, n=8; dLck-Cre, n=3; CK2αfl/fldLck-Cre, n=10. * CK2αfl/fl compared to CK2αfl/fldLck-Cre; # dLck-Cre compared to CK2αfl/fldLck-Cre. (B) Colon length and (C) colon weight. Each dot represents one mouse. (D) Representative pictures of recipient colon sections stained with H&E. (E) Pathological scores of colons in recipient mice. (F) Cytokines and chemokines in serum were detected by Multiplex ELISA. Data represent pooled results from three independent experiments. CK2αfl/fl, n=6; CK2αfl/fldLck-Cre, n=10. Bars represent the mean ± SD. * p<0.05, ** p<0.01, *** p<0.001, ****p<0.0001, ## p<0.01, ### p<0.001.