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. 2020 Jul 22;14:2927–2935. doi: 10.2147/DDDT.S254466

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© 2020 He et al.

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Triptolide induced the differentiation of IL22-stimulated HaCaT cells via upregulating miR-181b-5p. HaCaT cells were transfected with miR-181b-5p antagomir and exposed to 10 μM triptolide for 24 h, and then treated with 100 ng/mL of IL22 for 24 h. (A) Expressions of FILAGGRIN, INVOLUCRIN, KERATIN 1 and KERATIN 10 in cells were detected with Western blotting. (B–E) The relative expressions of FILAGGRIN, INVOLUCRIN, KERATIN 1 and KERATIN 10 in cells were quantified via normalization to BETAACTIN. **P < 0.01, compared with the control group. ^#P < 0.05, ^##P < 0.01 compared with the 100 ng/mL IL22 group. ^{^}P < 0.05, ^{^^}P < 0.01 compared with IL22 + triptolide group.