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. 2020 Jul 22;3(9):e201900619. doi: 10.26508/lsa.201900619

Figure 1. BH4 supplementation recovers cardiac systolic dysfunction in a rat model of late-stage type 2 diabetes mellitus.

Figure 1.

(A) Experimental design. (B, C) Body weight (B) and i.p. glucose-tolerance tests (n = 5/group) (C). (D) Representative M-mode echocardiography at 50 wk. (E) Fractional shortening during pretreatment and after 1 and 2 wk of BH4 or vehicle treatment (n = 5/group). (F) 2D echocardiography results. (G) Comparison of radial strain (n = 5/group). (H) Average traces of electrical stimulation–induced sarcomere shortening in isolated left ventricle (LV) cardiomyocytes (n = 15 cells from three animals/group). (I) Peak shortening of isolated LV cardiomyocytes (n = 15/group). (J) Velocity of shortening and Re-lengthening of isolated LV cardiomyocytes (n = 15/group). *P < 0.05 versus Long–Evans Tokushima Otsuka; #P < 0.05 versus Otsuka Long–Evans Tokushima Fatty.