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. 2020 Jul 22;3(9):e201900619. doi: 10.26508/lsa.201900619

Figure 3. BH4 supplementation improves the biochemical phenotype of diabetic rat hearts.

Figure 3.

(A) Total biopterin and BH4 level in heart and mitochondria (n = 4/group). (B) BH4/total biopterin ratios (n = 4/group). (C) Serum levels of CPK and LDH. (D) ATP levels. (E) Mitochondrial membrane potential. (F) Reactive oxygen species production assessed by relative Amplex Red intensity. (G) Lipid oxidation assay to measure oxidative stress in heart tissue. (H, I, J, K, L) Activities of OXPHOS complexes I–V. (M) Citrate synthase activity. *P < 0.05 versus Long–Evans Tokushima Otsuka; #P < 0.05 versus Otsuka Long–Evans Tokushima Fatty.