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. 2020 Jul 22;3(9):e201900619. doi: 10.26508/lsa.201900619

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© 2020 Kim et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 4. — (A) Differently expressed proteins between Otsuka Long–Evans Tokushima Fatty (OLETF) and OLETF/BH4 hearts and related cardio-relevant biological pathways. Red circles represent proteins directly linked to four biological pathways (direct links). Purple circles represent proteins that interact with red-circle proteins (second link). Blue circles represent proteins that interact with purple-circle proteins (third link). (B) Four biological pathways and their component proteins. (C) Enrichment P-values of four BH4 targets related to cardio-relevant biological pathways associated with heart function in the DCM model. (D, E) Immunoblot analysis of proteins related to mitochondrial biogenesis and functional regulation of (D) mitochondrial OXPHOS complexes (E) (n = 3/group). ATP5A for complex V, UQCRC2 for complex III, SDHB for complex II, and NDUFSB8 for complex I. Relative protein expression was normalized to β-actin. *P < 0.05 versus Long–Evans Tokushima Otsuka; ^#P < 0.05 versus OLETF. P/T, phosphorylated:unphosphorylated (total) protein ratio.

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