Individual maps of immune cell activation. Individual maps of innate immune cell activation in one HC (A) and in 3 patients with MS characterized by sparse (B), intermediate (C), and extensive (D) innate immune cell activation. Lesional inactive voxels in patients are represented in white, whereas voxels characterized by significant activation of innate immune cells are displayed in yellow in NAWM, in dark red in perilesional areas, and in light red inside T2 lesions.