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. 2020 Jul;61(7):1006–1013. doi: 10.2967/jnumed.119.234708

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© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 4. — (A) Hematoxylin and eosin staining of pancreas section from 113-d-old KPC mouse harvested 24 h after administration of ¹¹¹In-anti-γH2AX-TAT. (B) Identification of various morphopathologic features. (C) Autoradiography image showing distribution of radioactivity. (D) Immunofluorescence image showing γH2AX (green) and nuclei (blue). Additional sections are shown in Supplemental Figure 6. (E) Magnification of histologic areas in A–D. (F) Uptake of ¹¹¹In-anti-γH2AX-TAT in various morphopathologic features in KPC pancreata, measured by ex vivo autoradiography of pancreas sections. (G) Uptake of ¹¹¹In-IgG-TAT in various morphopathologic features in KPC pancreata, measured by ex vivo autoradiography of pancreas sections. Autorad = autoradiography; H&E = hematoxylin and eosin; IHC = immunohistochemistry; lymph = lymphocytes.