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Biodistribution of radiolabeled anti-mCD38 in C57BL/6 healthy mice. (A) For postmortem biodistribution studies, mice were injected with 185 kBq of 212Pb-anti-mCD38. Radioactivity was expressed as %ID/g of tissue. (B) For in vivo studies, mice were imaged by small-animal SPECT/CT 2, 6, 24, 48, and 96 h after injection of 203Pb-anti-mCD38 (7.4 MBq). Ing. LN = inguinal lymph node; Mes. LN = mesenteric lymph node; MIP = maximum-intensity projection; S = spleen.
