Table 1.

Studies of rapid vs. gradual weaning and intermittent vs. continuous CSF drainage of EVDs after SAH

Reference	Design	Number of centers	Number of subjects	Comparison	Outcomes	Findings
Klopfenstein 2004 [6]	RCT	1	81	Rapid vs. gradual	VPS, LOS	Rapid had shorter ICU and hospital LOS
Amato 2011 [7]	Prospective observational	1	37	Intermittent vs. continuous	VSP, EVD complications	No difference
Kim 2011 [8]	Prospective observational	1	37	Intermittent vs. continuous	VSP, EVD complications	No difference
Olson 2013 [9]	RCT	1	60	Intermittent vs. continuous	VSP, EVD complications	Intermittent had fewer EVD complications
Jabbarli 2018 [10•]	Retrospective	2	965	Rapid vs. gradual	VPS, LOS, complications	Gradual had fewer VPS and longer LOS
Rao 2019 [11••]	Retrospective	1	152	Intermittent/rapid vs. continuous/gradual	VPS, VSP, LOS, EV complications	Intermittent/rapid had fewer VPS and shorter LOS

RCT, randomized clinical trial; VSP, symptomatic vasospasm; VPS, ventriculoperitoneal shunt placement; LOS, length of stay