Skip to main content
. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Cell Rep. 2020 Jul 7;32(1):107855. doi: 10.1016/j.celrep.2020.107855

Figure 4. trNK Apoptosis Is the Consequence of Higher Sensitivity to Lactic Acid.

Figure 4.

(A) Liver lactate levels 36 h post-MCMV infection (n = 12–13).

(B) LDH RNA transcript expression at steady state and on day 1.5 post-MCMV infection (representative of two experiments, n = 5).

(C) Frequency of Annexin V+ liver cNK (gray) and trNK (red) cells following 4-h incubation at the indicated concentrations of lactic acid (n = 9).

(D) Frequency of MitoTracker-positive liver cNK (gray) and trNK (red) cells at steady state and on days 1 and 14 post-MCMV infection (n = 7).

(E) Representative gating of MitoTracker+ frequencies on liver cNK (gray) and trNK (red) cells.

Data are representative of (E) or pooled from 2–3 experiments (A–D); error bars indicate SEM. *p < 0.05, **p < 0.01,***p < 0.001, and ****p < 0.0001.