Table 4.

List of probable targets for organ-specific toxicity.

Sr. No.	Major organ toxicity	Possible targets
1	Cardio Toxicity	Human B2-adrenergic G protein-coupled receptor, Human cytochrome P450 2D6, human histamine HI receptor, cytochrome P450 3A4
2	Hepatotoxicity	Human HMG-COA reductase, Tesis ACE co-crystal structure, human cyclooxygenase-2
3	Nephrotoxicity	Human thymidylate synthase, human androgen receptor, aminoglycoside 4’-O-adenylyltransferase ANT(4’)-IIb, human Renin, human methionine aminopeptidase 2, human cathepsin G, recombinant human dihydrofolate reductase, human microsomal P450 1A2, structure of adenylate kinase mutants, human cytochrome P450 2E1, rat mitochondrial P450 24A1 S57D, cytochrome P450 CYP11A1, DNA polymerase beta mutant 5P20, cytosol aminopeptidase, oligomeic turkey beta1-adrenergic g protein-coupled receptor, human methionine aminopeptidase 2, Human cathepsin G, recombinant human dihydrofolate reductase, cytochrome P450 CYP11A1
4	Neurotoxicity	Apo human homogentisate dioxygenase, adenylate cydases, human monoamine oxidase B, prostaglandin h2 synthase-1, mammalian cytochrome P450 2B4, catechol o-methyltransferase, UDP-glucuronic acid binding domain, cyclohexanone monooxygenase, amino terminal domain of the NMDA receptor subunit NR2B, human dopamine D3 receptor, Atu4243-GABA receptor, human insulin, binding protein of ABC transporter, human acetylcholinesterase, human microsomal cytochrome P450 (CYP) 2C19