Table 3.
Allelic and genotypic association analysis
| SNP ID | NAION patients (n = 94) | Controls (n = 204) | p value | OR (95% CI) | |
|---|---|---|---|---|---|
| rs1801133 C677T | |||||
| Allele | C | 56.91 | 62.50 | 0.91 (0.72–1.14) | |
| T | 43.09 | 37.50 | 0.1945 | 1.15 (0.82–1.61) | |
| Genotype | CC | 31.91 | 40.69 | 0.6037a | 0.78 (0.54–1.14) |
| CT | 50.00 | 43.63 | 1.15 (0.85–1.54) | ||
| TT | 18.09 | 15.69 | 1.15 (0.62–2.14) | ||
| total | 30/47/17 (CC/CT/TT) | 83/89/32 (CC/CT/TT) | 0.3494 | ||
| rs1801131 A1298C | |||||
| Allele | A | 71.28 | 69.61 | 1.02 (0.86–1.22) | |
| C | 28.72 | 30.39 | 0.6791 | 0.94 (0.62–1.45) | |
| Genotype | AA | 51.06 | 48.53 | 0.8224a | 1.05 (0.80–1.39) |
| AC | 40.43 | 42.16 | 0.96 (0.69–1.33) | ||
| CC | 8.51 | 9.31 | 0.91 (0.38–2.22) | ||
| total | 48/38/8 (AA/AC/CC) | 99/86/19 (AA/AC/CC) | 0.9158 | ||
Statistical significance: p < 0.05. Total indicates the general test of association in the 2-by-3 table of disease-by-genotype. CI, confidence interval; NAION, nonarteritic anterior ischemic optic neuropathy; OR, odds ratio; SNP, single nucleotide polymorphism.
a
p values derived from comparison of the genotypic frequencies under the recessive model (TT vs. CT + CC at rs1801133 and CC vs. AC + AA at rs1801131).