Table 1.
Clinical and pathological features of patients with gallbladder adenocarcinoma over 45 years old.
| Variable | Variable level | N | Training cohort | Validation cohort | P value |
|---|---|---|---|---|---|
| (n = 1612) | (n = 1212) | (n = 400) | |||
| n (%) | n (%) | n (%) | |||
| Age | <65 | 543 (33.7) | 412 (34.0) | 131 (32.8) | 0.648 |
| ≥65 | 1069 (66.3) | 800 (66.0) | 269 (67.2) | ||
| Marital status | Married | 895 (55.5) | 675 (55.7) | 220 (55.0) | 0.809 |
| Unmarried | 717 (44.5) | 537 (44.3) | 180 (45.0) | ||
| Race | White | 1213 (75.2) | 917 (75.7) | 296 (74.0) | 0.362 |
| Black | 194 (12.0) | 138 (11.4) | 56 (14.0) | ||
| Other | 205 (12.7) | 157 (13.0) | 48 (12.0) | ||
| Sex | Male | 492 (30.5) | 381 (31.4) | 111 (27.8) | 0.165 |
| Female | 1120 (69.5) | 831 (68.6) | 289 (72.2) | ||
| Grade | Well, I | 218 (13.5) | 166 (13.7) | 52 (13.0) | 0.692 |
| Moderately, II | 775 (48.1) | 580 (47.9) | 195 (48.8) | ||
| Poorly, III | 596 (37.0) | 451 (37.2) | 145 (36.2) | ||
| Undifferentiated, IV | 23 (1.4) | 15 (1.2) | 8 (2.0) | ||
| AJCC 8th T stage | T1 | 150 (9.3) | 112 (9.2) | 38 (9.5) | 0.363 |
| T2 | 802 (49.8) | 604 (49.8) | 198 (49.5) | ||
| T3 | 602 (37.3) | 458 (37.8) | 144 (36) | ||
| T4 | 58 (3.6) | 38 (3.14) | 20 (5.0) | ||
| LODDS | LODDS1 | 518 (32.1) | 397 (32.8) | 121 (30.2) | 0.648 |
| LODDS2 | 642 (39.8) | 478 (39.4) | 164 (41.0) | ||
| LODDS3 | 452 (28.0) | 337 (27.8) | 115 (28.7) | ||
| AJCC 8th M stage | M0 | 1365 (84.7) | 1024 (84.5) | 343 (85.8) | 0.542 |
| M1 | 245 (15.2) | 188 (15.5) | 57 (14.2) | ||
| LN surgery scope | None | 40 (2.5) | 31 (2.6) | 9 (2.3) | 0.942 |
| 1 ~ 3 | 1080 (67.0) | 811 (66.9) | 269 (67.2) | ||
| 4~ | 492 (30.5) | 370 (30.5) | 122 (30.5) | ||
| Radiation | Yes | 385 (23.9) | 299 (24.7) | 86 (21.5) | 0.197 |
| No/unknown | 1227 (76.1) | 913 (75.3) | 314 (78.5) | ||
| Chemotherapy | Yes | 678 (42.1) | 513 (42.3) | 165 (41.2) | 0.705 |
| No/unknown | 934 (57.9) | 699 (57.7) | 235 (58.8) | ||
| Tumor size (cm) | <1.9 | 355 (22.0) | 273 (22.5) | 82 (20.5) | 0.218 |
| 1.9~4.8 | 895 (55.5) | 657 (54.2) | 238 (59.5) | ||
| ≥4.8 | 362 (22.5) | 282 (23.3) | 80 (20.0) |
AJCC: American Joint Committee on Cancer; LODDS: log of positive lymph nodes; LN: lymph nodes.