Table 2.

Univariate and multivariate Cox regression analyses of OS for patients with gallbladder adenocarcinoma in the training cohort.

Characteristics	Variable level	Univariate analysis			Multivariate analysis
		HR	95% CI	P value	HR	95% CI	P value
Age (years)				<0.001∗∗∗			<0.001∗∗∗
	≤65	Reference			Reference
	>65	1.55	1.317-1.824	<0.001∗∗∗	1.686	1.400-1.988	<0.001∗∗∗
Marital status				0.016∗			0.001∗∗
	Married	Reference			Reference
	Unmarried	1.2	1.035-1.39	0.016∗	1.298	1.117-1.508	0.001∗∗
Race				0.003∗∗			0.11
	White	Reference
	Black	0.757	0.591-0.971	0.028∗			0.47
	Other	0.712	0.559-0.906	0.006∗∗			0.062
Sex				0.516
	Male	Reference					NI
	Female			0.516
Grade				<0.001∗∗∗			0.06
	I	Reference			Reference
	II	1.385	1.071-1.79	0.013∗	1.234	0.952-1.600	0.112
	III	1.947	1.503-2.523	<0.001∗∗∗	1.237	0.947-1.615	0.119
	IV	4.396	2.474-7.81	<0.001∗∗∗	2.295	1.282-4.109	0.005∗∗
T stage				<0.001∗∗∗			<0.001∗∗∗
	T1	Reference			Reference
	T2	1.565	1.112-2.202	0.01∗	1.229	0.868-1.741	0.245
	T3	3.639	2.59-5.114	<0.001∗∗∗	2.424	1.699-3.459	<0.001∗∗∗
	T4	6.902	4.287-11.112	<0.001∗∗∗	3.715	2.262-6.101	<0.001∗∗∗
LODDS				<0.001∗∗∗			<0.001∗∗∗
	LODDS1	Reference			Reference
	LODDS2	1.525	1.262-1.842	<0.001∗∗∗	1.316	1.087-1.593	0.005∗∗
	LODDS3	3.228	2.659-3.919	<0.001∗∗∗	2.515	2.053-3.080	<0.001∗∗∗
M stage				<0.001∗∗∗
	M0	Reference			Reference
	M1	3.04	2.531-3.651	<0.001∗∗∗	2.067	1.704-2.508	<0.001∗∗∗
LN surgery scope				0.003∗∗
	None	Reference					NI
	1~3	1.462	0.825-2.593	0.193
	≥4	1.12	0.625-2.005	0.704
Radiation				0.289
	Yes	Reference					NI
	No/unknown	1.217	0.991-1.493	0.289
Chemotherapy				0.512
	Yes	Reference					NI
	No/unknown	1.084	0.925-1.271	0.512
Tumor size (cm)				<0.001∗∗∗			0.003∗∗
	<1.9	Reference			Reference
	1.9~4.8	1.605	1.31-1.965	<0.001∗∗∗	1.176	0.952-1.453	0.132
	≥4.8	2.611	2.084-3.271	<0.001∗∗∗	1.503	1.179-1.916	0.001∗∗

AJCC: American Joint Committee on Cancer; LODDS: log of positive lymph nodes. Level of significance: ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001.