Table 2.

Review of gene therapy experiments

Reference	Gene type	Subject	CL (ms)	APD50 (ms)	APD90 (ms)	MDP (mV)	V 1/2 (mV)	I f density at −70 mV (pA/pF)
Qu et al., 2003	HCN2	Canine left atrium					−94.00	−3.2
Plotnikov et al., 2004	HCN2	Canine left bundle-branch	340	100	180	−74.7		−31.0
Qu et al., 2001	HCN2	Neonatal rat VMs	681	170	255	−42.5±1.6# (n=11)	−78.00	−41.3
Boink et al., 2013	HCN2/SkM1	Canine left bundle-branch	625	195±5# (n=6)	213±5# (n=6)	−85.0±2.0# (n=6)
Valiunas et al., 2009	Mouse HCN2	Canine VMs	648	266	479	−66.0
Cho et al., 2007	HCN1	Guinea pig VMs	279	113	155	−70.0		−12.5
Miake et al., 2002	Kir2.1-AAA	Guinea pig VMs	598	230	295	−63.0
Zaritsky et al., 2001	Kir2.1 −/−	Neonatal mouse VMs	Non*					−11.7±1.2# (n=8)
Kapoor et al., 2013	TBX18	Neonatal rat VMs	631	242	320	−47.0±10.0# (n=6)	−3.46	−8.0
		Guinea pig VMs	443	137	189	−55.8±6.0# (n=5)
Hu et al., 2014	TBX18	Porcine VMs	730
Bakker et al., 2012	TBX3	Neonatal rat VMs	580

HCN: hyperpolarization-activated cyclic nucleotide-gated; HCN1/2: HCN channel 1/2; SkM1: skeletal muscle sodium channel 1; TBX18: transcription factor T-box 18; VMs: ventricular myocytes; CL: cycle length; APD₅₀: action potential duration at 50% repolarization; APD₉₀: action potential duration at 90% repolarization; MDP: maximum diastolic potential; V _1/2: average half-maximal activation voltage of funny current’s activation gate; I _f: funny current; pA/pF: unit of current density, (10⁻¹² A)/(10⁻¹² F).

^*No auto-rhythm was observed;

^#Data are expressed as mean±standard error of the mean (SEM)