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. 2020 Jul 17;2020:5149417. doi: 10.1155/2020/5149417

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Copyright © 2020 Jianwen Long and Xianming Pi.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Polyphyllin I suppressed melanoma A375 cell migration and invasion in a dose-dependent manner. (a, c) A375 cell migration as measured by Wound healing assays was inhibited by Polyphyllin I treatment, but IGF-1 treatment mitigated extremely the inhibitory function of Polyphyllin I in A375 cell migratory capability. (b, d) A375 cell invasion as determined by Transwell assays was suppressed distinctly by Polyphyllin I treatment. However, IGF-1 treatment relieved dramatically the inhibitory function of Polyphyllin I in A375 cells invasive capability. ^∗P < 0.05 in comparison with 0 mg/L PPI group; ^#P < 0.05 in comparison with 6 mg/L PPI group. Note: 1: 0 mg/L PPI group; 2: 1.5 mg/L PPI group; 3: 3.0 mg/L PPI group; 4: 6.0 mg/L PPI group; 5: 6.0 mg/L PPI +20 mg/L IGF-1 group.