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. 2020 Jul 17;2020:5149417. doi: 10.1155/2020/5149417

Figure 4.

Figure 4

Polyphyllin I treatment affected A375 cells apoptosis in vitro. (a, b) Polyphyllin I treatment enhanced obviously A375 cells apoptosis. (c, d) Western blot assays manifested that the expressions of Bax and cleaved caspase-3 were increased distinctly, but the level of Bcl-2 was significantly decreased in A375 cells after Polyphyllin I treatment in comparison with 0 mg/L Polyphyllin I group. However, IGF-1 treatment alleviated distinctly the above mentioned functions of Polyphyllin I in A375 cells apoptosis. ∗P < 0.05 in comparison with 0 mg/L PPI group; #P < 0.05 in comparison with 6 mg/L PPI group. Note: 1: 0 mg/L PPI group; 2: 1.5 mg/L PPI group; 3: 3.0 mg/L PPI group; 4: 6.0 mg/L PPI group; 5: 6.0 mg/L PPI +20 mg/L IGF-1group.