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. 2020 Jun 26;12(6):248–261. doi: 10.4330/wjc.v12.i6.248

Table 2.

International Takotsubo Diagnostic Criteria (InterTAK Diagnostic Criteria)[8]

No. International Takotsubo Diagnostic Criteria
1 Transient left ventricular dysfunction (hypokinesia, akinesia, dyskinesia), manifests as apical ballooning or mid-ventricular, basal or focal wall motion abnormality, which usually extend beyond a single epicardial vascular distribution. Right ventricular involvement can be present
2 A mental, physical or mixed cause can precede the event of Takotsubo syndrome but this is not necessary
3 Takotsubo syndrome can be caused by neurological conditions (e.g. subarachnoid hemorrhage, stroke/transient ischemic attack, or seizures) as well as pheochromocytoma
4 Electrocardiogram changes (elevation or depression of the ST-segment, inversion of the T-wave and prolongation of the QTc); however, there are unusual cases without electrocardiogram changes
5 Elevation of cardiac biomarkers (troponin and creatine kinase)
6 Significant coronary artery disease could also be present in Takotsubo syndrome
7 Exclusion of acute myocarditis, in this case cardiovascular magnetic resonance is recommended
8 The pathology is common in postmenopausal women are predominantly affected