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Diverse functions of shelterin proteins
| Shelterins | Telomeric DNA binding | Chromatin organization | Gene regulation | Maintenance of the dedifferentiated state | Cancer stem cell | References |
|---|---|---|---|---|---|---|
| TRF1 | dsDNA | ✓ | ✗ | ✓ | ✗ | 4, 55–57, 86, 96, 97 |
| TRF2 | dsDNA | ✓ | ✓ | ✓ | ✓ | 4, 24, 58–62, 76, 77, 98–106 |
| RAP1 | ✗ | ✗ | ✓ | ✓ | ✓ | 4, 19, 46–52 |
| POT1 | ssDNA | ✗ | ✗ | ✓ | ✗ | 4, 109, 110 |
| TIN2 | ✗ | ✓ | ✓ | ✗ | ✗ | 4, 53, 54 |
| TPP1 | ✗ | ✗ | ✗ | ✓ | ✗ | 4, 107, 108 |
