Table 1.
Patient Characteristics and Immunosuppression According to Randomized Treatment Groups
| EVR Group (n = 65) | TAC Group (n = 78) | |
|---|---|---|
| Sex, male | 56 (86.2) | 68 (87.2) |
| Age, years* | 57 (9) | 56 (8) |
| Race, white | 61 (93.8) | 74 (94.9) |
| Body mass index, kg/m2 | 23.6 (3.5) | 23.4 (4.2) |
| Reason for liver transplantation | ||
| Alcoholic cirrhosis | 35 (53.8) | 40 (51.3) |
| HCC | 12 (18.5) | 23 (29.5) |
| HCV | 6 (9.2) | 6 (7.7) |
| HBV | 2 (3.1) | 2 (2.6) |
| Other | 10 (15.4) | 7 (9.0) |
| Diabetes† | 20 (30.8) | 23 (29.5) |
| Cold ischemia time ≥12 hours | 5 (7.7) | 3 (3.8) |
| Immunosuppression at month 6 after transplant | ||
| EVR | 60 (92.3) | 3 (3.8) |
| CNI therapy | 15 (23.1) | 77 (98.7) |
| TAC | 15 (23.1) | 76 (97.4) |
| CsA | 0 (0.0) | 1 (1.3) |
| MPA | 53 (81.5) | 69 (88.5) |
| Steroids | 37 (56.9) | 41 (52.6) |
| Immunosuppression at month 24 after transplant‡ | ||
| EVR | 44 (69.8)§ | 18 (24.3) |
| CNI therapy | 29 (46.0) | 68 (91.9) |
| TAC | 28 (44.4) | 67 (90.5)|| |
| CsA | 1 (1.6) | 1 (1.4) |
| MPA | 50 (79.4) | 60 (81.1) |
| Steroids | 19 (30.2) | 19 (25.7) |
Data are given as mean (SD) or n (%).
*
At randomization in the SIMCER study.
†
At entry to the SIMCER study.
‡
EVR group, n = 63; TAC group, n = 74.
§
31 patients also received TAC at month 24.
||
19 patients also received EVR at month 24.