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. 2020 Jan 8;287(13):2847–2861. doi: 10.1111/febs.15177

Figure 2.

Figure 2

Kinetic plots with respect to fructose 6‐phosphate titrations for Trypanosoma cruzi PFK (TcPFK) (Inline graphic, blue line), Trypanosoma brucei PFK (TbPFK) (Inline graphic, dotted red line) and Leishmania infantum PFK (LiPFK) (Inline graphic, dot‐dashed green line) show different kinetic properties for each enzyme. Effects of 1 mm AMP, shown alongside for TcPFK (□, pale blue line), YbPFK (○, dotted red line) and LiPFK (△, dot‐dashed green line) show disproportionate activation for LiPFK. Data were fitted with a sigmoidal curve given by the equation for a cooperative (allosteric) model (n = 3; error bars represent standard deviations; 1.5 mm ATP).